RNA G-quadruplexes (rG4s): genomics and biological functions
In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and important functions of rG4 being …
rG4-seq reveals widespread formation of G-quadruplex ... - Nature
Aug 29, 2016 · Using rG4-seq on polyadenylated-enriched HeLa RNA, we generated a global in vitro map of thousands of canonical and noncanonical rG4 structures.
RNA G-quadruplexes: emerging regulators of gene expression ...
Jul 3, 2025 · Despite methodological limitations and challenges in achieving targeted delivery, rG4s represent a compelling frontier for precision medicine. This review outlines current insights and future …
G4Atlas
RNA G-quadruplex (rG4) is a vital RNA tertiary structure motif that involves the base pairs on both Hoogsteen and Watson-Crick faces of guanines. rG4 is of great importance in the post …
G-Quadruplexes in RNA Biology: Recent Advances and Future ...
Apr 1, 2021 · RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression mechanisms, from transcription to protein synthesis, and DNA-related processes.
RNA G-quadruplexes (rG4s): genomics and biological functions
Jun 4, 2021 · In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and important …
RNA G-quadruplexes (rG4s): genomics and biological functions
Mar 27, 2021 · In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and important …
Specific Targeting and Imaging of RNA G-Quadruplex (rG4 ...
Sep 3, 2024 · RNA G-quadruplex structures (rG4s) play important roles in the regulation of biological processes. So far, all the l -RNA aptamers developed to target rG4 of interest contain G4 motif itself, …
Identification of G-quadruplex nucleic acid structures by ...
Mar 1, 2025 · rG4-seq combines reverse transcriptase stalling with high-throughput sequencing to identify RNA G4 formation and stability across the transcriptome, revealing unique structural …