RNA G-quadruplexes (rG4s): genomics and biological functions
In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and important functions of …
rG4-seq reveals widespread formation of G-quadruplex ... - Nature
Aug 29, 2016 · Using rG4-seq on polyadenylated-enriched HeLa RNA, we generated a global in vitro map of thousands of canonical and noncanonical rG4 structures.
RNA G-quadruplexes: emerging regulators of gene expression and ...
Jul 3, 2025 · Despite methodological limitations and challenges in achieving targeted delivery, rG4s represent a compelling frontier for precision medicine. This review outlines current …
G-Quadruplexes in RNA Biology: Recent Advances and
Apr 1, 2021 · RNA G-quadruplexes (RG4s) are four-stranded structures known to control gene expression mechanisms, from transcription to protein synthesis, and DNA-related processes.
G4Atlas
RNA G-quadruplex (rG4) is a vital RNA tertiary structure motif that involves the base pairs on both Hoogsteen and Watson-Crick faces of guanines. rG4 is of great importance in the post …
RNA G-quadruplexes (rG4s): genomics and biological functions
Jun 4, 2021 · In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and …
RNA G-quadruplexes (rG4s): genomics and biological functions
Mar 27, 2021 · In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and …
Properties and biological impact of RNA G-quadruplexes: from …
Dec 12, 2020 · While formation of DNA G4s (dG4s) within chromatin in vivo has been supported by different chemical, imaging and genomic approaches, formation of RNA G4s (rG4s) in vivo …
Specific Targeting and Imaging of RNA G-Quadruplex (rG4) …
Sep 3, 2024 · RNA G-quadruplex structures (rG4s) play important roles in the regulation of biological processes. So far, all the l -RNA aptamers developed to target rG4 of interest …
RNA G-quadruplex structure-based PROTACs for targeted DHX36 …
Jan 30, 2025 · Here, we have rationally designed and developed a series of rG4-based proteolytic targeting chimeras (rG4-PROTACs) aimed at degrading G4BPs, such as DHX36, a specific …