imageimageThe GndRX system in Legionella pneumophila is a predicted toxin-antitoxin module that causes death during DNA stress. GndRX has non-canonical functionality and appears to be the consequence ...

imageimageSTING inhibits LINE-1 retrotransposition to maintain genomic stability in an IFN-independent manner. STING interacts with LINE-1 ORF1p, sorting ORF1p to lysosomes for degradation. STING ...

RNA interference (RNAi) is widely used in life science research and is critical for diverse biological processes, such as germline development and antiviral defense. In the germline of Caenorhabditis ...

Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing promoter or ...

Symbiotic bacteria in long-term host associations frequently undergo extreme genome reduction. While they retain genes beneficial to the host, their repertoire of transcription factors is severely ...

Hemorrhage is a major pathological manifestation of certain viral infections, such as severe fever with thrombocytopenia syndrome (SFTS), Ebola, Crimean-Congo hemorrhagic fever and Dengue. SFTS is an ...

imageimageThe tubulin/FtsZ superfamily of cytoskeletal proteins may have originated in Asgard archaea. This study reveals different filament morphologies membrane tethering mechanisms for the dual ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bacterial cell wall is primarily composed ...

Phospholipase C gamma 1 (PLCG1) has been identified as the most frequently mutated gene in adult T-cell leukemia/lymphoma, suggesting a critical function of PLCG1 in driving T cell activation. However ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. DNA N 6-methyladenine (6mA) is an emerging ...