The San Francisco 49ers can breathe a sigh of relief following the latest update on Isaac Guerendo’s injury status. However, there’s still a long road ahead to determine if his recovery will be complete in time for the upcoming NFL season.

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. He was

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona Cardinals. On San Francisco's opening series and on Guerendo's second carry,

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ season finale in Arizona against the Cardinals with a leg injury.

Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

The San Francisco 49ers’ practice schedule began a day later than normal with a Monday night showdown against the Detroit Lions coming up in Week 17. Their practice report opened with some good news on the injury front. Running back Isaac Guerendo returned as a limited participant after missing all of Week 16 with a hamstring injury.

San Francisco 49ers rookie running back Isaac Guerendo shared positive news on Monday morning, revealing via social media that he avoided a dreaded ACL injury, which would have jeopardized his 2025 season.