Cell biology: New proteomics technique gives insights into ubiquitin signaling. ScienceDaily . Retrieved May 30, 2025 from www.sciencedaily.com / releases / 2019 / 08 / 190814130728.htm ...

The study of death receptor (DR) signaling has led to the discovery of new signaling paradigms, including the first example of direct receptor-mediated activation of a protease (caspase-8) that ...

Ubiquitous and influential New insights into the intricate molecular underpinnings of ubiquitin signaling Date: February 13, 2017 Source: Julius-Maximilians-Universität Würzburg, JMU ...

A new signaling pathway, which is important for the regulation of the immune response and inflammation, was discovered by an international team of scientists led by prof Ivan Dikic from the Goethe ...

The past decade has witnessed an explosion in the identification of ubiquitin-ligase complexes as the missing receptors for important small-molecule hormones regulating plant growth and development.

“We isolated some 40 different genes in yeast that, when mutated, altered the delivery of proteins to the lysosomes,” Emr said. The ubiquitin binding domains in carboxypeptidase were ...

Ubiquitin does more than mark proteins for degradation. In 2004, Ingrid Wertz, a University of California, Davis graduate student, and advisor Vishva Dixit of Genentech, demonstrated that the protein ...

David Komander, PhD, head of WEHI’s Ubiquitin Signaling Division, said years of work by his team have now unlocked that mystery. “This is a significant milestone for research into Parkinson’s.

Endosomal stress, a newly defined organelle stress, induces inflammation via ubiquitin signaling. Tokyo Metropolitan Institute of Medical Science. Journal Journal of Cell Biology DOI 10.1083/jcb ...

The scientific founders of Entact bring expertise in proteomics, biochemistry, structural sciences, ubiquitin signaling, and more, Richon says.

More information: PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance, Nature Communications (2025). DOI: 10.1038/s41467-025-56974-9.

Prof. Scott Emr, molecular biology, earned the 2021 Shaw Prize for Life Science and Medicine for unpacking the secrets of a set of proteins that are able to detect key molecular signals to ...