Fixed block signaling divides the tracks into blocks, or sections of roughly 1,000 feet on average, that carry an electrical current. When a train occupies a block, it cuts off the current ...

David Komander, PhD, head of WEHI’s Ubiquitin Signaling Division, said years of work by his team have now unlocked that mystery. “This is a significant milestone for research into Parkinson’s.

Plants are constantly under siege by pathogens, and their survival depends on precise internal defense strategies. A new ...

AUTHORS: Yu Cai, Yumei Wu KEYWORDS: GSPT2, Tumor, Biomarker, Cell Cycle, Signaling JOURNAL NAME: Journal of Cancer Therapy, Vol.16 No.1, January 13, 2025 ABSTRACT: GSPT2 (G1 to S phase transition ...

This “push” signal is balanced by a “pull” signal, driven by the ubiquitin ligase, Siah2. Ubiquitin ligases facilitate the recycling of defunct proteins.

Synopsis Upon activation, STING traffics to the Golgi and induces NF-κB signaling through poorly understood mechanisms. This study shows that E3 ligase HOIP recruitment to STING-positive Golgi-related ...

It will be interesting to determine if these K63-ubiquitin chains are homotypic or heterotypic with M1 ubiquitin chains (i.e., hybrid K63/M1-Ub chains) (Emmerich et al, 2013) or conjugated to specific ...

Reviews in ubiquitin signaling: 2022 This collection of reviews highlights the central role that ubiquitin, and ubiquitin-like proteins, play in biology and how hypothesis driven use of new and ...

UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the ...

Entact launched on Dec. 6 with $81 million in funding to develop two-ended small molecules that strip the ubiquitin from a beneficial protein. One end of the molecule binds the protein while the ...

The researchers found that USP11 chopped ubiquitin from 20 lysine residues, exposing them to acetylation. Tau acetylated at lysine 281 (K281Ac) was three times as insoluble as wild-type tau, they ...

Emr Recognized for Establishing Importance of Signaling in Recruiting ESCRT Proteins By Omsalama Ayoub Jun 9, 2021 7:05 pm · Updated Aug 4, 2021 9:39 am Reading time: about 3 minutes ...