Mutations in EGLN1, the gene encoding for hypoxia-inducible factor (HIF) prolyl-4-hydroxylase 2 (PHD2), cause erythrocytosis and in rare cases the development of neuroendocrine tumors. In the presence ...

The ubiquitin ligase LNX (ligand of numb-protein X) can ubiquitinate Numb, preventing internal sequestration of Notch, resulting in enhanced downstream Notch signaling. 13 The ubiquitin ligase Itch ...

This valuable manuscript provides convincing evidence that BK and CaV1.3 channels can co-localize as ensembles early in the biosynthetic pathway, including in the ER and Golgi. The findings, supported ...

Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps ...

This protein interacts with immune receptors to signal that a cell is safe and should not be destroyed. When this signaling pathway weakens or fails, the immune system mistakenly targets the body's ...