Explore novel therapies for IgA nephropathy that target inflammation and antibody production. Learn how these advancements ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...

The market for TIGIT inhibitors is expected to grow significantly in the coming years. This is due to the increasing number ...

Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same ...

FDA Fast Track designation has been granted to CTx001 for Geographic Atrophy secondary to Age-related Macular Degeneration CTx001 is an investigational AAV-based gene therapy designed to modulate ...

Scientists have spotted a new variety of riled-up microglia that drives swelling in the human brain. In the November 18 Neuron, researchers from China led by Haixiao Liu, Shunnan Ge, and Yan Qu at ...

Now researchers from Japan's Okayama University of Science have found another way bitter taste receptors function in cancer cells. They discovered that the receptors, known as TAS2Rs, become activated ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in ...

A complex interplay of mechanisms and cell types regulates synapse stabilization and pruning throughout life. The complement cascade contributes by activating glia, leading to pruning. Neurons also ...

Expert Rev Clin Immunol. 2008;4(3):379-390. Since there are no genetic deficiencies of CRP in man, animal models have been used to study the role of CRP in inflammatory disease. Two methods have been ...

The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and ...