Immuno-Metabolic Mechanisms of Atherosclerosis (2020) Atherosclerosis remains a leading cause of death worldwide, characterised by plaque build-up in artery walls. Dysregulation of lipid homeostasis ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

imageimageThis study developed a systematic workflow leveraging transcriptomics and metabolomics to identify input signals for 41 transcription factors in E. coli. A systematic workflow was developed ...

Xenobiotics like drugs are recognised as key influencers of gut bacterial growth. Yet, their impact on the production of metabolites involved in microbiota–host interactions is largely unknown. Here, ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

FANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study presents and characterizes a Dnmt3a ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

imageimageThis study identifies a pathway for oxidation and assembly of mitochondrial inner membrane proteins. Dbi1 is a conserved mitochondrial inner membrane protein that interacts with the ...

imageimageEBNALP alters looping factor YY1 DNA binding and 3D genome organization which might facilitate cell cycle progression and prevent cell death. EBNALP is tethered to DNA by DPF2. EBNALP ...

How loss of KIF4A chromokinesin reduces chromosome association of condensin has remained unclear. This study demonstrates that human condensin I is auto-inhibited by short linear motifs (SLiMs) in its ...

Gpr54 deletion lowers NFATC3 and SFRP1 levels, activates the Wnt/β-catenin pathway, which stimulates DPCs and HFSCs, and accelerates hair cycle and hair regeneration.