A historic College Football Playoff semifinal kicks off at the Orange Bowl as Notre Dame and Penn State square off with a shot at the national championship game

Get our expert betting predictions for the evenly-matched CFP semifinal clash between Notre Dame and Penn State.

The Fighting Irish opened as favorites against the Nittany Lions for the semifinal set to take place in the Orange Bowl. Notre Dame opened as a 2.5-point favorite, but the spread is -1 on the day of the game.

Notre Dame head coach Marcus Freeman celebrates after winning the first round of the College Football Playoff 27-17 against Indiana at Notre Dame Stadium on Friday, Dec. 20, 2024, in South Bend. / MICHAEL CLUBB/SOUTH BEND TRIBUNE / USA TODAY NETWORK via Imagn Images

Our college football expert has whipped up a three-leg same game parlay for Thursday's Notre Dame vs. Penn State College Football Playoff semifinal.

Adam Silverstein, on a 16-2 run (+1375) on Penn State picks, has revealed his CFP semifinal predictions for the Notre Dame Fighting Irish vs. Penn State Nittany Lions in the 2025 Orange Bowl on Thursd

Find out why Riley Leonard & Co. has Douglas Farmer bullish on the Over ahead of Thursday's CFP semifinal at Hard Rock Stadium in his Notre Dame vs Penn State predictions.

Members of the Notre Dame Fighting Irish are reportedly battling a flu outbreak in their locker room ahead of Thursday's College Football Playoff semifinal.

Here's a look at the series history between Penn State and Notre Dame heading into their College Football Playoff semifinal matchup.

Notre Dame players and staff members are dealing with a "flu or a virus" ahead of Thursday night's College Football Playoff semifinal against Penn State, a school official confirmed in a statement to CBS Sports' Brandon Marcello.