Different receptors are specific for different ... Through this network of signaling pathways, the cell is constantly integrating all the information it receives from its external environment.

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes ...

Michael Rieger from Universitätsmedizin Frankfurt's Department of Medicine II, has now molecularly decoded the differentiation pathways of human blood stem cells into all specialized blood cell ...

Michael Rieger from Universitätsmedizin Frankfurt's Department of Medicine II, has now molecularly decoded the differentiation pathways of human blood stem cells into all specialized blood cell ...

More information: Dave Maurice De Sousa et al, Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation, Journal of Experimental Medicine (2025). DOI: 10. ...

In vertebrates, the skeleton of different regions of the body arises from different precursor cells. Researchers at the University of Basel have now discovered that these skeletal cells do not just ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

Yet “something was missing,” according to coauthor Jay Tan, a cell biologist at the University of Pittsburgh. Up to 90 percent of lysosomal damage is fixed even when the ESCRT complex is inhibited, ...

This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...

Get Instant Summarized Text (Gist) The NOTCH signaling pathway is crucial for the differentiation of CD8 + T cells, essential for an effective immune response. This process begins early, with ...