Morphologically indistinct from T-LGLL, diagnosis hinges on flow cytometric identification of aberrant NK-cell receptor expression (e.g., restricted KIR isoforms, altered CD94/NKG2A). STAT3 and ...

Technological advances empower the modification of NK cells and renewed potential for therapeutic uses in cancer and ...

The proposal, titled "Cell Type Specificity of Neurokinin-1 Receptor Antagonists on Cognitive Improvement," aims to understand the precise neurological mechanisms and cellular targets responsible ...

"There are probably more immunologists working on adhesive molecules," says Harvard Medical School biologist Timothy A. Springer, "than there are on T cell receptors." Springer should know. His ...

They designed and generated PD-1 BiKE that targets an activating NK cell receptor, CD16, and PD-1. PD-1 BiKE showed specific binding to PD-1 + cells and engaged CD16 simultaneously.

Immunotherapy. 2011;3(9):1075-1086. MIP-1β release has also been observed for CD56 neg NK cells from patients with HCV infection. The above results suggest that the aberrant CD56 neg NK subset ...

However, age-related shifts in NK cell subpopulations provide a basis for hypothesizing potential mechanisms linking Immunosenescence to MS pathophysiology. Age-associated declines in perforin ...

We previously reported a novel adaptor protein, ARAP, required for T cell receptor signaling and integrin-mediated adhesion. The present study investigates further the role of ARAP in T cell biology ...

IPAH dependent changes mediated through cell type distinct extracellular matrix response. A) Ligand-receptor interaction analysis for PAAF and PASMC based on transcriptomic and proteomic data set. B) ...