Ubiquitination is a post-translation modification in which ubiquitin chains or single ubiquitin molecules are appended to target proteins, giving rise to poly- or monoubiquitination, respectively1 ...

Now, coupled monoubiquitination has been shown to involve monoubiquitination of a ubiquitin ligase and its subsequent interaction with a ubiquitin receptor. Nature Cell Biology ...

Gupta-Rossi et al., "Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor," J Cell Biol, 166:73–83, July 5, 2004.This paper is important because it shows that the ...

The Fanconi Anemia pathway, named after a cancer-predisposition syndrome, is essential for the repair of DNA-interstrand crosslinks (ICLs). The pathway consists of 22 FA complementation group proteins ...

Similarly to monoubiquitination, ubiquitin chain can also affect the function of receptor proteins on the membrane of cells and lead to cell death in that manner. References.