In the manuscript entitled "Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans" by ...

Synopsis The exact molecular interplay between ATR activation and Rad18-dependent PCNA monoubiquitination, along with the broader physiological implications of this interaction, remain unclear. This ...

KRAS, a 21 kDa guanine nucleotide-binding protein that functions as a molecular switch, plays a key role in regulating cellular growth. Dysregulation of this key signaling node leads to uncontrolled ...

Monoubiquitination Monoubiquitination refers to when a single ubiquitin protein binds to one protein substrate. This type of ubiquitination is thought to be associated with certain cellular ...

Thank you for submitting your article "Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays" for consideration by eLife. Your article has been reviewed ...

Translesion DNA synthesis (TLS) bypasses DNA lesions encountered during S-phase and is critical for cell survival after exposure to DNA-damaging agents. In humans, Rad6/Rad18 attaches single ubiquitin ...

More information: Yue Zhou et al. H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity, Genome Biology (2017). DOI: 10.1186/s13059-017-1197-z ...

H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biology, 2017; 18 (1) DOI: 10.1186/s13059-017-1197-z ...

Monoubiquitination in proteasomal degradationThe study by Braten et al. in PNAS (18) demonstrates that mono- and multimonoubiquitinated proteins are commonly processed by proteasomes, more than we ...

Monoubiquitination of FANCD2 is essential to its function in ICL repair. A point mutation of lysine 561 to arginine, leads to a complete loss of function of the protein.

Unlike the polyubiquitination associated with protein degradation or signal complex formation, monoubiquitination alters R‐SMAD and Co‐SMAD complex formation or transcriptional complex assembly. The ...