The answer lies in transcription factors. Experiments have shown ... a higher level of control over genes involved in cell development and differentiation. The cells of higher organisms exhibit ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

to enable the activation of other transcription factors that will induce the changes required (gene expression) for CD8 + T cell differentiation. "There was some evidence that fibroblasts in the ...

A research team has uncovered the mechanism and underlying reason behind the transformation of residual cells into epidermal ...

Loss of Notch signaling therefore causes excess neural differentiation ... BEND6 is a co-repressor for the Notch transcription factor CBF1 and inhibits neural stem cell self-renewal. Development 140: ...

The method, called "Perturb-multiome," uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell analyses on ...

A new method can be used to identify factors involved in the specialization of naïve endothelial cells to tissue-specific endothelial cells.

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

It appeared to reduce lipid accumulation – how much fat cells store ... in adipocyte differentiation by evaluating gene expression and protein level of adipogenic transcription factors ...