to enable the activation of other transcription factors that will induce the changes required (gene expression) for CD8 + T cell differentiation. "There was some evidence that fibroblasts in the ...

Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

A new method can be used to identify factors involved in the specialization of naïve endothelial cells to tissue-specific endothelial cells.

It appeared to reduce lipid accumulation – how much fat cells store ... in adipocyte differentiation by evaluating gene expression and protein level of adipogenic transcription factors ...

This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

Researchers have uncovered a surprising mechanism by which a single genetic mutation in the BCL11B gene causes both immune dysfunction and brain development issues.