For a cell to regulate the cell cycle in response to a variety of internal and external factors as such ... whose mechanism encompases periodic transcription and degradation of the cyclin ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Cancer drugs that inhibit CDK7 rapidly shut down pathways responsible for cell proliferation within minutes. For organs to ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

The method, called "Perturb-multiome," uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell analyses on ...

In multicellular organisms, how do multiple cell types originate ... “germness” and the cell cycle governs the establishment of cellular identity during development. A major challenge is identifying ...

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... of proteins called transcription factors, which influence ...

The latest insights into transcription factors provide a deeper understanding of the disease's progression and potential therapeutic interventions. Transcription factors are critical proteins that ...