and eventually led to the identification of cyclin dependent kinases (CDKs) as regulators of progression through the cell cycle. Deregulating CDK activity by changes in phosphorylation ...

The viral cyclin encoded by Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) facilitates both cell-cycle progression and apoptotic cell death. Although they seem a paradoxical pair, the cell ...

An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...