Through co-culture with tumor cells, we evaluate CAR dynamic change, activation levels, exhaustion markers, mitochondrial function, and differentiation ... anti-human CD25 antibody (BioLegend, 302606) ...

2.5 Immunophenotyping of naïve and retrieved BM-MSCs For immunophenotyping, cells were stained using antibodies (Supplementary Table S1) targeting CD105, CD106, CD146, CD44, and Ly-6A/E (Sca-1) ...

The creation of these fighting cells requires new programming of CD8 + T cells, a process known as differentiation. Previous work by the team had shown that the NOTCH signaling pathway played a ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

The scientists showed that, right at the onset of mild illness, the body also produces special T cells previously known only from chronic, severe infections and tumors. There are different types ...

Quantification of Microsatellite Instability Testing and Detection of Lynch Syndrome: Step Forward in Improving Mismatch Repair Testing in Clinical Practice The introduction of T-cell–based ...

The scientists showed that, right at the onset of mild illness, the body also produces special T cells previously known only from chronic, severe infections and tumors. There are different types ...

A team from the Max Planck Research Group for Systems Immunology at the University of Würzburg has identified a previously ...

There’s no cell phone sitting here. There’s never a cell phone around me. Never.” How come? “I don’t want to be distracted by it,” explained Kiper. “Nobody needs me that desperately.

IO360º presented the 2025 award to Dr Mackall for her pioneering work in T-cell therapies, which has transformed treatment approaches and advanced novel therapies for patients. Through her career ...