The new workflow was adapted from an enzymatic DNA tagging technology, DNA-TAG, previously developed in the Devaraj lab. In ...

There are only so many ways to cram DNA into a cell’s nucleus, a study suggests. A cell’s complete genetic blueprint, or genome, is densely packed into chromosomes, condensing meters of DNA into a ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Chromosomes are thread-like structures that carry a cell's ...

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the ...

When DNA is damaged, it remains in the cytoplasm instead of being incorporated into the nucleus during cell division and thus acts as an indicator of damage. These findings suggest that colibactin, ...

In an era where the U.S. healthcare system spends $4.5T annually yet faces systemic failures, with life expectancy plummeting to a three-decade low and chronic disease rates at an all-time high, the ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Subscribe to our newsletter for the latest sci-tech news updates.