The viral cyclin encoded by Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) facilitates both cell-cycle progression and apoptotic cell death. Although they seem a paradoxical pair, the cell ...

The irreversibility of cell-cycle transitions is commonly thought ... that blocks the activity of Cdk–cyclin complexes, Cdk activity can be reduced in the absence of cyclin degradation.

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation," said ... cancer researchers and pharmaceutical companies have eyed ...

An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...

The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... companies have eyed cyclin-dependent kinase (CDK7) with ...