A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA. How do cells detect non-self ...
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CRISPR system variant shows a novel DNA cleavage mechanismResearchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system ... bound to double-stranded DNA (dsDNA), with the target DNA strand ...
one of the most complex and understudied CRISPR-Cas types. We have previously demonstrated that this system is capable of acquiring new spacers by two distinct modes—one arising from transcribed ...
The precise insertion of DNA sequences using the homology-directed repair (HDR) pathway is one potential use of the CRISPR/Cas genome editing ... Comparing GenWandTM dsDNA to internal PCR dsDNA ...
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