Researchers have revealed for the first time how a key protein linked to Parkinson's mutates, leads to cell death in the ...

The researchers have established that specific intracellular types of living bacteria possess special enzymes which allow them to permanently remove what is referred to as ubiquitin marking. This ...

A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Researchers have discovered more about PINK1, a protein that’s directly tied to Parkinson’s disease. A team from Walter and Eliza Hall Institute in Australia has shown how the protein attaches to cell ...