Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their ...

Once human proteins are synthesized, they go through some chemical changes. These adjustments control their stability, ...

Mutation of a necroptosis-related ubiquitination site on RIP1 reduced necroptotic cell death and RIP1 ubiquitination and phosphorylation, and disrupted the assembly of RIP1 and RIP3 in the ...

Ubiquitination, a fundamental post-translational modification, plays a pivotal role in protein stability, cellular signaling, and gene expression, particularly in the context of CSCs.

Researchers studying these processes may be interested in a new technique that can measure ubiquitination—and deubiquitination—in real time.

The team also discovered that preventing BRAF ubiquitination reduced tumor growth in mice, suggesting that blocking ITCH activity or BRAF ubiquitination may be an effective treatment approach.