Ubiquitination is a relatively common process in humans. Approximately 3 % of the human genome, or more than 600 E3 ligase genes, are involved in ubiquitination's diverse range of biological ...

Ubiquitination, a fundamental post-translational modification, plays a pivotal role in protein stability, cellular signaling, and gene expression, particularly in the context of CSCs.

Ubiquitination (*2) of a protein called PAF15 (*3) is an important factor for the inheritance of DNA methylation, according to the new research. The group also successfully demonstrated a ...

The team also introduced mutations to amino acids at the ubiquitination site of PAF15 in mouse ES cells, and found that the level of DNA methylation in the whole genome was greatly reduced, ...

More information: Franziska Günl et al, The ubiquitination landscape of the influenza A virus polymerase, Nature Communications (2023). DOI: 10.1038/s41467-023-36389-0.

29 Nov 2004. Ubiquitination, sumoylation (tagging with small ubiquitin-like modifiers), ubiquitinated aggregates, and problems with ubiquitin-mediated proteasomal degradation have all been linked to ...