UbiREAD: Cracking the ubiquitin code of protein degradation
Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...
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Scientists solve decades-long Parkinson's mystery
Corresponding author on the study and head of WEHI's Ubiquitin Signaling Division, Professor David Komander, said years of ...
Technology Networks3d
Researchers Reveal Antiviral Pathway in Rice Crops
Though recent discoveries have revealed how rice plants mitigate such threats by initiating immune responses against ...
GEN - Genetic Engineering and Biotechnology News13d
Structure of Key Parkinson’s Disease Protein, PINK1, Seen for First Time
Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.
Neuroscience News5d
Sleep-Deprived Fruit Flies Show Sharper Memory via PKA Signaling
Fruit flies with genetic mutations that severely reduce sleep show enhanced performance in olfactory memory tasks, ...
EurekAlert!3d
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...
Informationsdienst Wissenschaft2d
Cracking the Code of Protein Degradation
Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...