Why do our cells age? Part of the answer is hidden at the very ends of our chromosomes, where telomeres are located. These ...

Telomerase synthesizes DNA sequences that protect the integrity of chromosome ends. A model for how the components of this enzyme complex co-assemble offers insight into its structure and function.

Study shows how telomerase can run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage. The natural ends of chromosomes appear alarmingly like broken DNA, much as ...

Telomerase may be a nearly universal anticancer drug target: Inhibitors of this human enzyme might be able to treat most cancers without significant side effects. Telomerase is an enzyme that ...

Researchers have found a way to trap telomerase, the enzyme cancer cells rely on for endless division, in a stalled and non-productive state. The discovery, published in Nature Communications, used ...

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Our DNA is organized into chromosomes, and the ends of chromosomes are protected with caps called telomeres; when cells divide, they lose a very small amount of DNA from those ends. Short telomeres ...

Cancer, aging-related diseases and other illnesses are closely tied to an important enzyme called "telomerase." UCLA researchers report in the journal Cell the deepest scientific understanding yet of ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Neuroblastoma is a pediatric solid tumor of the sympathetic nervous system. 1 Clinical courses of patients with neuroblastoma vary greatly, ranging from spontaneous regression to fatal progression.

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway ...