Brain organoids have shown promise in neurological disease modelling and drug screening. However, their application is limited by several factors, including their heterogeneity and poor ...

This review was designed by Professor Hongcui Cao (State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine).

Human gut cells grown on an Invasin coating produce high numbers of all cell types. The 2D structure enabled by Invasin preserves the natural organization of cells and makes both sides of the cell ...

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids they ...

Pea-sized brains grown in a lab have for the first time revealed the unique way neurons might misfire due to schizophrenia and bipolar disorder, psychiatric ailments that affect millions of people ...

Since Madeline Lancaster first created brain organoids back in 2013, they have become widely used for brain research around the world. But what exactly are they? Are they effectively miniature brains ...

Lab-grown “reductionist replicas” of the human brain are helping scientists understand fetal development and cognitive disorders, including autism. But ethical questions loom. Brain organoids, which ...

Organoids are bits of neural tissue that model human brain development. Their use in science makes some uneasy, in part because the brain is so closely tied to our sense of self. Research on ...

Our cells are continually being exposed to environmental assaults. For instance, skin is exposed to pollutants and UV radiation. Our lungs are subject to environmental stimuli such as smoke ...

Until now, it has been difficult to maintain retinal ganglion cells deep inside organoids over extended periods. The supply of nutrients and oxygen in the densely packed tissues is limited, leading to ...