GEN

Combining Protein Shapes with Genomic Sequences Improves Reliability of Evolutionary Trees

New research headed by scientists at the Centre for Genomic Regulation (CRG) has demonstrated how the three-dimensional shape of a protein can be used to resolve deep, ancient evolutionary ...
The New England Journal of Medicine

A Holy Grail — The Prediction of Protein Structure

This year’s Lasker Basic Medical Research Award recognizes the contributions of Demis Hassabis and John Jumper for their invention of the AlphaFold artificial intelligence (AI) system, which predicts ...
EurekAlert!

Expanding the sequence spaces of synthetic binding protein using deep learning-based framework ProteinMPNN

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...
GEN

AI Predicts Protein Aggregation from Sequence to Address Neurological Disease

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...