In vertebrates, the skeleton of different regions of the body arises from different precursor cells. Researchers at the University of Basel have now discovered that these skeletal cells do not just ...

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes ...

Michael Rieger from Universitätsmedizin Frankfurt’s Department of Medicine II, has now molecularly decoded the differentiation pathways of human blood stem cells into all specialized blood cell types.

More information: Dave Maurice De Sousa et al, Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation, Journal of Experimental Medicine (2025). DOI: 10. ...

This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...

Previously unknown access points in cell membrane proteins have been discovered, enabling laboratory-developed drugs to modify cell function. The discovery was made possible through computer ...

But what if we can reprogram T cells so that they can use a different nutrient? "We turned to the metabolic pathways that govern T cell functioning to identify mechanisms that can help them thrive ...