The Sooners took an early lead, but late pitching struggles allowed South Carolina to take game two of the series on Saturday.
The Sooners' all-time winningest coach with 851 victories, Semore guided OU to five CWS trips and 14 straight NCAA Tournaments and had his jersey retired last spring.
Oklahoma (14-1) swept a three-game series against Sam Houston (3-12) 6-5, 7-3 and 9-7 at L. Dale Mitchell Park.
He's the winningest head coach in program history. More: Why OU baseball retiring former coach Enos Semore's jersey was 'really important' "We are deeply saddened by the passing of Coach Enos ...