For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...

Using a novel quantitative chemoproteomic strategy, a research group led by Prof. Wang Chu from the College of Chemistry and ...

Their findings, published in Developmental Cell, shed light on how a protein called CDK5RAP2 activates the microtubule ...

The microtubule-associated protein XMAP215 promotes microtubule growth, but how this occurs has been unclear. To address this question, Gary Brouhard et al. developed a single-molecule ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Specifically, tau fragments containing the microtubule binding region and its adjacent C-terminal sequence wreaked havoc on synaptic plasticity when injected into rat brains. Scientists led by Michael ...

The research group led by Prof. Wang Chu from the College of Chemistry and Molecular Engineering at Peking University ...

Akhmanova and colleagues have identified an interaction between the ER membrane resident, stromal interaction molecule 1 (STIM1), and the microtubule plus-end-binding protein EB1, which is ...

The research group led by Prof. Wang Chu from the College of Chemistry and Molecular Engineering at Peking University published a research article ...

HIV-1 Vif induces a unique and prolonged pseudo-metaphase arrest by disrupting phosphatase feedback regulation at the kinetochore.

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau. This discovery ...