IL-11 is known to promote the development of colorectal cancer in humans and mice, but when and where IL-11 is expressed during cancer development is unknown. "To address these questions ...

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according ...

IL-11 is known to promote the development of colorectal cancer in humans and mice, but when and where IL-11 is expressed during cancer development is unknown. "To address these questions ...

Interleukin-2, a cytokine that helps the immune system fight disease, is an FDA-approved treatment, but it has been associated with selectivity, toxicity and dosing issues. Those shortcomings have ...

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD).

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival. Background: The inflammatory cytokine IL-6 is a major component of an autocrine cytokine ...

tuberculosis In patients with rheumatologic diseases, treatment with interleukin inhibitors may increase the risk of serious infections, opportunistic infections, and cancer, according to a systematic ...

No single definition of cytokine storm or the cytokine release syndrome is widely accepted, and there is disagreement about how these disorders differ from an appropriate inflammatory response. The ...

Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to carrying a high risk of bowel cancer, also greatly increases the risk of duodenal cancer. At present, the only ...