The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

New gene mapping technique reveals how genetic alterations in cells lining blood vessels contribute to coronary artery disease, with implications for diagnostic and treatment strategies. The mapping ...

The ability of different genetic variants—changes to one or more building blocks of DNA—to cause disease, and to what extent, has historically been opaque. Geneticist and Crick group leader Greg ...

New gene editing techniques, like adenine base editing and prime editing, are creating new possibilities for treating dilated cardiomyopathy, a heart condition affecting about 1 in 250 people ...

Engineered proteins that can cross the blood–brain barrier represent a reliable and non-invasive way to map gene expression in the brains of large animals. Gene therapy has been successfully used to ...

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to reveal disruptions in gene function in three brain regions of patients with ...