For at least the last decade, protein purification has increasingly been viewed as a process bottleneck—not just for individual unit operations, but for the entire purification train. Current wisdom ...
Upstream titers of 3–5 g/L, and up to 10–13 g/L, are outpacing downstream capacity, creating chromatography, filtration, and UF/DF throughput bottlenecks that elevate cost and delay timelines. Complex ...
Downstream Operations Can Relieve the Pressure of Higher Titers and Cell Densities without Undue Disruption Platform manufacturing keeps driving the industrialization of bioprocessing, both upstream ...
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