The answer lies in transcription factors. Experiments have shown ... a higher level of control over genes involved in cell development and differentiation. The cells of higher organisms exhibit ...

Sequence-specific transcription factors are considered the ... But at the core of cellular differentiation, manifested in the variety of cell types observed in different organisms, is the ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Collaborative research defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation. The method, ...

to enable the activation of other transcription factors that will induce the changes required (gene expression) for CD8 + T cell differentiation. "There was some evidence that fibroblasts in the ...

A new method can be used to identify factors involved in the specialization of naïve endothelial cells to tissue-specific endothelial cells.

The method, called "Perturb-multiome," uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell analyses on ...

SRY-box transcription factor 9. Bone morphogenetic protein 2 (BMP-2) can induce the differentiation of mesenchymal stem cells (MSCs) into different osteocyte cells, including chondrocytes ...

Researchers have struggled to unravel what causes cryptic transcription in human cells because cryptic transcripts are difficult to detect and distinguish from other RNA transcripts with traditional ...

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

It appeared to reduce lipid accumulation – how much fat cells store ... in adipocyte differentiation by evaluating gene expression and protein level of adipogenic transcription factors ...