For a cell to regulate the cell cycle in response to a variety of internal and external factors as such ... whose mechanism encompases periodic transcription and degradation of the cyclin ...

Cancer drugs that inhibit CDK7 rapidly shut down pathways responsible for cell proliferation within minutes. For organs to ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... that it controls the function of proteins called transcription ...

The method, called "Perturb-multiome," uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell analyses on ...

Cellular senescence, the permanent state of cell-cycle arrest ... and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative ...

The latest insights into transcription factors provide a deeper understanding of the disease's progression and potential therapeutic interventions. Transcription factors are critical proteins that ...

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... of proteins called transcription factors, which influence ...