A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... that it controls the function of proteins called transcription ...

Cancer drugs that inhibit CDK7 rapidly shut down pathways responsible for cell proliferation within minutes. For organs to develop, grow, and regenerate, cells must divide and multiply, a process ...

Cellular senescence, the permanent state of cell-cycle arrest ... and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

The method, called "Perturb-multiome," uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell analyses on ...

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

In multicellular organisms, how do multiple cell types originate ... “germness” and the cell cycle governs the establishment of cellular identity during development. A major challenge is identifying ...

One of my lab's long-term goals is to elucidate the transcriptional and epigenetic mechanisms regulating retinal progenitor cell proliferation and differentiation ... Recently, we have uncovered a ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

As a consequence, high-affinity B cell lineages should frequently degrade ... affinity B cells had elevated levels of a key transcription factor that indicates when T cells are helping B cells ...