Cyclic AMP-responsive element-binding protein (CREB) mediates induction of cAMP-responsive genes following its phosphorylation at Ser133 by protein kinase A (PKA). CREB phosphorylation increases its ...

Scientists have designed and developed novel biosensors that allow the simultaneous study of both sensory evoked neuronal activity and transcription factor dynamics. Our brains have a remarkable knack ...

Scientists have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver. They ...

Despite increasing evidence linking alcohol consumption to cancer, little is known about the biological mechanisms behind the association. A new study, published Aug. 12 in Cellular and Molecular ...

Scientists know that the ravages of Alzheimer disease cripple the ability to lay down new memories, but the precise molecular dance that determines the success or failure of memory formation is still ...

No man is an island, and no neuron is either: complex, intricate connections between and among brain cells are needed for the brain to do its job correctly. Now, researchers from Japan have uncovered ...

A single center retrospective cohort study of patients with metastatic breast cancer and leptomeningeal disease: Updated survival data and subgroup analyses by breast cancer subtype. Updated safety ...

Investigators at St. Jude Children's Research Hospital have discovered how a single molecular “on switch” triggers gene activity that might cause effects ranging from learning and memory capabilities ...