Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables ...

The homeostasis of adherens junctions was studied using E-cadherin and its two mutants tagged by the photoconvertible protein Dendra2 in epithelial A-431 cells and in CHO cells lacking endogenous ...

Researchers report the first evidence in living organisms that adherens junctions, the 'glue' between cells, actively respond to mechanical cues by remodeling their position and intensity, which in ...

Adherens junctions, the sites of cadherin-dependent cell–cell adhesion, are also important for dynamic tension sensing, force transduction and signalling. Different myosin motors contribute to ...

Embryonic development, wound healing or cancer metastases: cell-to- cell adhesion plays an important role in these and many other patho-physiological processes. The cellular mechanisms behind this ...

Using super-resolution microscopy, an international research team has revealed, for the first time, how cadherin-based cell-cell contacts are organized. The development of super resolution microscopy ...