Christian McCaffrey, Kyren Williams, & Najee Harris have carried heavy workloads in their NFL careers. Injury concerns will raise caution in fantasy football.

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The 49ers may provide an indication of how they're feeling about their RB depth in the days ahead. If they sign another ...

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

Mackenzie Brooks and the Inside the Lines Team break down where every NFC West team's season is most likely to end and how to ...

The 49ers are hoping to rebound from a lost season in 2024 and Christian McCaffrey's return from injury will be a major boost ...

San Francisco's Christian McCaffrey revealed the unteachable traits that make 49ers QB Brock Purdy "so special." ...

Two top contenders this year face off in the preseason opener, with the San Francisco 49ers hosting the Denver Broncos. However, many fans are wondering whether stars Christian McCaffrey and Bo Nix ...

Puni’s 1,078 snaps led the 49ers, just ahead of center Jake Brendel (1,072) and right tackle Colton McKivitz (1,062). Yet ...

This is the second installment on fantasy drafting. Today it's running backs. (Find my article on wide receivers here.) There are more good receivers than running backs—and/or there is an earlier and ...

Christian McCaffrey was the number one draft pick in fantasy football leagues in 2024, but he missed nearly the entire season.

San Francisco 49ers’ Christian McCaffrey (23) runs with the ball against Kansas City Chiefs’ Leo Chenal (54) in the first half at Levi’s Stadium in Santa Clara, Calif., on Sunday, Oct. 23, 2022.